Studies of the in Vitro Antibacterial Activities of Several Polyphenols against Clinical Isolates of Methicillin-Resistant Staphylococcus aureusReport as inadecuate




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1

Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

2

Clinical Laboratory Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China





*

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Abstract In this study, we report the antibacterial activities of six polyphenols i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol against 29 clinical isolates of methicillin-resistant Staphylococcus aureus MRSA, and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremia. The antibacterial activities were determined by agar dilution method, and the two-drug antibacterial activities were determined by the checkerboard agar dilution method. It was found that luteolin, quercetin and resveratrol show obvious antibacterial activities against MRSA, and the results of two-drug antibacterial activity show either synergy or additivity, without evidences of antagonistic effects. View Full-Text

Keywords: methicillin-resistant Staphylococcus aureus; polyphenols; antibacterial activity; synergism methicillin-resistant Staphylococcus aureus; polyphenols; antibacterial activity; synergism





Author: Yanli Su 1, Liyan Ma 2, Yan Wen 1, Hong Wang 1 and Shuwen Zhang 1,*

Source: http://mdpi.com/



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