Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L.Report as inadecuate




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1

Grupo de Genética Molecular y Departamento de Fisiología y Bioquímica, Facultad de Medicina, Universidad de Antioquia, Calle 67 No. 53-10, Medellín 050010, Colombia

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Grupo de Quimica Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Calle 67 No. 53-10, Medellín 050010, Colombia





*

Author to whom correspondence should be addressed.



Academic Editor: Isabel C. F. R. Ferreira

Abstract Jatropha gossypifolia L. Euphorbiaceae is a plant widely used in the treatment of type 2 diabetes mellitus T2DM, but there are few scientific reports validating its activity in this area. In this work and through a bioguided assay, a crude extract stimulated glucose uptake in C2C12 myotubes up to 30%, thereby reducing insulin resistance induced by fatty acids compared to the basal control. A chromatographic fraction applied intraperitoneally IP in mice reduced glucose by 42% in a mouse model of T2DM, after administration of 10 doses during 20 days. A flavanone was purified from this active fraction and its structure was assigned by 1H- and 13C-NMR 1D and 2D and MS. This compound retains the previously reported activity, stimulating in vitro the glucose uptake in a concentration-dependent manner. This study indicates that Jatropha gossypifolia L. extracts enhance glucose uptake in cultured myotubes and adipocytes and also improving glucose tolerance in an in vivo model. View Full-Text

Keywords: Jatropha gossypifolia L.; flavanone; flavone; glucose regulation; myotubes; mice Jatropha gossypifolia L.; flavanone; flavone; glucose regulation; myotubes; mice





Author: Sergio Granados 1, Norman Balcázar 1, Alis Guillén 1 and Fernando Echeverri 2,*

Source: http://mdpi.com/



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