Synthesis of Novel Pyrido4,3-e1,2,4triazino3,2-c1,2,4thiadiazine 6,6-dioxide Derivatives with Potential Anticancer ActivityReport as inadecuate




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1

Department of Organic Chemistry, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland

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Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Ul. Kładki 24, 80-822 Gdańsk, Poland

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Department of Human Physiology, Medical University of Gdańsk, Ul. Tuwima 15, 80-210 Gdańsk, Poland





*

Author to whom correspondence should be addressed.



Academic Editor: Jean Jacques Vanden Eynde

Abstract A series of novel 3-2,3-substituted pyrido4,3-e1,2,4triazino3,2-c1,2,4thiadiazine 6,6-dioxides 4–28 have been synthesized by the reaction of 3-amino-2-4-thioxo-1,4-dihydropyridin-3-yl-sulfonylguanidine with either 2-oxoalkanoic acids and its esters, or phenylglyoxylic hydrates in glacial acetic acid. Some of them exhibited reasonable or moderate anticancer activity toward human cancer cell lines, HCT-116, MCF-7 and HeLa. The structure of this novel heterocyclic ring system was confirmed by 1D-NMR and 2D-NMR spectroscopic data including COSY, ROESY and HMBC, elemental analyses and MS spectrometry. View Full-Text

Keywords: pyrido4,3-e1,2,4triazino3,2-c1,2,4thiadiazine; 6,6-dioxides; synthesis; NMR studies; cytotoxic activity pyrido4,3-e1,2,4triazino3,2-c1,2,4thiadiazine; 6,6-dioxides; synthesis; NMR studies; cytotoxic activity





Author: Jarosław Sławiński 1,* , Aleksandra Grzonek 1, Beata Żołnowska 1 and Anna Kawiak 2,3

Source: http://mdpi.com/



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