Design, Synthesis and Antimycobacterial Activity of Novel Imidazo1,2-apyridine Amide-Cinnamamide HybridsReport as inadecuate




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1

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

2

Zhejiang Starry Pharmaceutical Co. Ltd., Xianju 317300, China

3

Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China





*

Authors to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract We report herein the design and synthesis of a series of novel imidazo1,2-apyridine amide-cinnamamide hybrids linked via an alkyl carbon chain. All 38 new hybrids were evaluated for their antimycobacterial activity against M. tuberculosis MTB H37Rv ATCC 27294 using the microplate Alamar Blue assay MABA. Although the hybrids are less active than the two reference compounds, the promising activity MICs: 4 μg-mL of 2,6-dimethylimidazo1,2-apyridine amide-cinnamamide hybrids 11e and 11k could be a good starting point to further find new lead compounds against multi-drug-resistant tuberculosis. View Full-Text

Keywords: imidazo1,2-apyridine amide-cinnamamide hybrids; design; synthesis; antimycobacterial activity imidazo1,2-apyridine amide-cinnamamide hybrids; design; synthesis; antimycobacterial activity





Author: Linhu Li 1, Zhuorong Li 1, Mingliang Liu 1,* , Weiyi Shen 2, Bin Wang 3, Huiyuan Guo 1 and Yu Lu 3,*

Source: http://mdpi.com/



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