Synthesis of Chlorinated Tetracyclic Compounds and Testing for Their Potential Antidepressant Effect in MiceReport as inadecuate




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Chemistry Department, College of Science, King Saud University, P. O. Box 2455 Riyadh 11451, Saudi Arabia

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Department of Pharmacology, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia





*

Author to whom correspondence should be addressed.



Academic Editor: Maria Emília de Sousa

Abstract The synthesis of the tetracyclic compounds 1-4,5-dichloro-9,10-dihydro-9,10-ethanoanthracen-11-yl-N-methylmethanamine 5 and 1-1,8-dichloro-9,10-dihydro-9,10-ethanoanthracen-11-yl-N-methylmethanamine 6 as a homologue of the anxiolytic and antidepressant drugs benzoctamine and maprotiline were described. The key intermediate aldehydes 3 and 4 were successfully synthesized via a 4 + 2 cycloaddition between acrolein and 1,8-dichloroanthracene. The synthesized compounds were investigated for antidepressant activity using the forced swimming test. Compounds 5, 6 and 3 showed significant reduction in the mice immobility indicating significant antidepressant effects. These compounds significantly reduced the immobility times at a dose 80 mg-kg by 84.0%, 86.7% and 71.1% respectively. View Full-Text

Keywords: chlorinated tetracyclic; antidepressants; synthesis; forced swimming test chlorinated tetracyclic; antidepressants; synthesis; forced swimming test





Author: Usama Karama 1,* , Mujeeb A. Sultan 1, Abdulrahman I. Almansour 1 and Kamal Eldin El-Taher 2

Source: http://mdpi.com/



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