The Protective Effects of Alisol A 24-Acetate from Alisma canaliculatum on Ovariectomy Induced Bone Loss in VivoReport as inadecuate




The Protective Effects of Alisol A 24-Acetate from Alisma canaliculatum on Ovariectomy Induced Bone Loss in Vivo - Download this document for free, or read online. Document in PDF available to download.

1

Department of Pharmacy, Sunchon National University, 255 Joongang-Ro, Seokhyeon-Dong, Suncheon 549-742, Korea

2

Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea





*

Author to whom correspondence should be addressed.



Academic Editor: Christopher W.K. Lam

Abstract Alisma canaliculatum is a herb commonly used in traditional Korean medicine, and has been shown in scientific studies to have antitumor, diuretic hepatoprotective, and antibacterial effects. Recently, the anti-osteoclastogenesis of alisol A 24-acetate from Alisma canaliculatum was investigated in vitro. However, the influence of alisol A 24-acetate on osteoporosis in animals has not been investigated. The present study was undertaken to investigate the anti-osteoporotic effect of alisol A 24-acetate on bone mass in ovariectomized OVX mice and to identify the mechanism responsible for its effects. OVX mice were treated daily with 0.5 or 2 μg-g of alisol A 24-acetate for a period of six weeks. It was found that these administrations significantly suppressed osteoporosis in OVX mice and improved bone morphometric parameters. The serum estradiol, bone alkaline phosphatase levels, regulatory T-Th17 cell numbers were significantly increased by alisol A 24-acetate as compared with untreated OVX mice. In addition, TRAP activity was inhibited by alisol A 24-acetate in OVX mice. These results suggest alisol A 24-acetate effectively prevents bone loss in OVX mice, and that it can be considered a potential therapeutic for the treatment of postmenopausal osteoporosis. View Full-Text

Keywords: osteoporosis; bone loss; alisol A 24-acetate; Alisma canaliculatum ; regulator T cell; traditional Korean medicine osteoporosis; bone loss; alisol A 24-acetate; Alisma canaliculatum ; regulator T cell; traditional Korean medicine





Author: Yun-Ho Hwang 1, Kyung-Yun Kang 1, Sung-Ju Lee 1, Sang-Jip Nam 2, Young-Jin Son 1 and Sung-Tae Yee 1,*

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents