Synthesis of Isotopically Labeled 13C3-Simazine and Development of a Simultaneous UPLC-MS-MS Method for the Analysis of Simazine in SoilReport as inadecuate




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1

Plant Protection Institute of the Chinese Academy of Agricultural Sciences, Beijing 100193, China

2

College of Pharmacology, Ningxia Medical University, Yinchuan 750004, China

3

School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract The isotope dilution mass spectrometry IDMS is a highly efficient method for tackling the ion suppression in complex matrix by ultra-performance liquid chromatography-tandem mass spectrometry UPLC-MS-MS, but a lack of commercial internal standards is a limiting factor for these analyses. Herein, an economical and efficient strategy for the synthesis of 13C3-simazine via a three-step procedure was developed. The isotope-labeled internal standard was used for determination of simazine residue in soil samples. The quantitation method has a limit of detection of 0.015 μg-kg and quantitation of 0.08 μg-kg. The inter-day and intra-day precision of the method were below 4.6%. Recovery values were ranged between 92.9% and 99.2%. All the samples obtained from six provinces in China contained from 1 to 62 μg-kg of simazine. View Full-Text

Keywords: 13C3-simazine; synthesis; IDMS; UPLC-MS-MS; isotope labelling 13C3-simazine; synthesis; IDMS; UPLC-MS-MS; isotope labelling





Author: Yan Song 1,2, Yangzhen Guo 1, Xia Zhang 1,3, Yue Yang 1,3, Shuo Chen 1, Gaimei She 3 and Dongmei She 1,*

Source: http://mdpi.com/



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