Total Synthesis of Chiral Falcarindiol Analogues Using BINOL-Promoted Alkyne Addition to AldehydesReport as inadecuate




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1

Department of Medicinal Chemistry, Sichuan Medical University, Luzhou 646000, China

2

Key Laboratory of Medicinal Electrophysiology of Ministry of Education, Sichuan Medical University, Luzhou 646000, China



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract An enantioselective total synthesis of chiral falcarindiol analogues from buta-1,3-diyn-1-yltriisopropylsilane is reported. The key step in this synthesis is BINOL-promoted asymmetric diacetylene addition to aldehydes. The two chiral centers of the falcarindiol analogues can be produced by using the same kind of catalyst with high selectivity, and the final product can be obtained in only six steps. View Full-Text

Keywords: falcarindiol analogues; total synthesis; diynol; BINOL; asymmetric addition; alkyne falcarindiol analogues; total synthesis; diynol; BINOL; asymmetric addition; alkyne





Author: Li Wang 1,†, Ping-Ping Shou 1,†, Si-Ping Wei 1, Chun Zhang 1, Shuang-Xun Li 1, Ping-Xian Liu 1, Xi Du 1 and Qin Wang 1,2,*

Source: http://mdpi.com/



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