A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 MicrogliaReport as inadecuate


A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia


A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia - Download this document for free, or read online. Document in PDF available to download.

1

Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea

2

Institute of Marine Biochemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi 100000, Vietnam

3

Hanbang Body-Fluid Research Center, Wonkwang University, Iksan 54538, Korea





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Cudrania tricuspidata Bureau Moraceae is an important source of traditional Korean and Chinese medicines used to treat neuritis and inflammation. Cudratricusxanthone A 1, a prenylated xanthone, isolated from C. tricuspidata, has a variety of biological and therapeutic activities. The goal of this study was to examine the effects of compound 1 on neuroinflammation and characterize its mechanism of action in lipopolysaccharide LPS-stimulated BV2 microglia. Cudratricusxanthone A 1 suppressed the expression of inducible nitric oxide synthase iNOS and cyclooxygenase COX-2 enzymes and decreased the production of iNOS-derived nitric oxide and COX-2-derived prostaglandin E2 in LPS-stimulated mouse BV2 microglia. The compound also decreased tumor necrosis factor-α, interleukin IL-1β, and IL-12 production; inhibited the phosphorylation and degradation of IκB-α; and blocked the nuclear translocation of p50 and p65 in mouse BV2 microglia induced by LPS. Cudratricusxanthone A 1 had inhibitory effects on nuclear factor kappa B DNA-binding activity. Additionally, it inhibited the p38 mitogen-activated protein kinase signaling pathway. Our data suggests that cudratricusxanthone A 1 may be a useful therapeutic agent in the treatment of neurodegenerative diseases caused by neuroinflammation. View Full-Text

Keywords: Cudrania tricuspidata; cudratricusxanthone A; microglia; neuroinflammation; nuclear factor-kappa B; mitogen-activated protein kinase Cudrania tricuspidata; cudratricusxanthone A; microglia; neuroinflammation; nuclear factor-kappa B; mitogen-activated protein kinase





Author: Chi-Su Yoon 1,†, Dong-Cheol Kim 1,†, Tran Hong Quang 2, Jungwon Seo 1, Dae Gill Kang 3, Ho Sub Lee 3, Hyuncheol Oh 1 and Youn-Chul Kim 1,3,*

Source: http://mdpi.com/



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