Synthesis of Substituted α-Trifluoromethyl Piperidinic DerivativesReport as inadecuate


Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives


Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives - Download this document for free, or read online. Document in PDF available to download.

Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation CBI, CNRS UMR 8231, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75231 Paris CEDEX 05, France





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Academic Editors: Margaret A. Brimble CNZM, FRSNZ

Abstract A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided 65 references. These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes-dienophiles by 4 + 2-cycloaddition. View Full-Text

Keywords: nitrogen heterocycles; fluorine; piperidine; trifluoromethyl group; ring expansion; cyclization; cycloaddition nitrogen heterocycles; fluorine; piperidine; trifluoromethyl group; ring expansion; cyclization; cycloaddition





Author: Sarah Rioton, Domingo Gomez Pardo and Janine Cossy *

Source: http://mdpi.com/



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