The Effects of Sweet Foods on the Pharmacokinetics of Glycyrrhizic Acid by icELISAReport as inadecuate


The Effects of Sweet Foods on the Pharmacokinetics of Glycyrrhizic Acid by icELISA


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School of Basic Medical Sciences, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China

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Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China

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School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China





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Academic Editor: Stefan Berger

Abstract The effect of sweet foods, such as honey, was investigated from the perspective of pharmacokinetics on the absorption of glycyrrhizic acid GA. Due to the unique properties of indirect competitive enzyme-linked immunosorbent assay icELISA, namely, its: specificity, sensitivity, repeatability, simple pretreatment of samples, fast and simple operation, and because it is economic and non-polluting, it has received increased attention. In this study, we used the advantages of this method to see how honey affected the pharmacokinetics of GA. The effects of honey on the pharmacokinetics of GA by ELISA were investigated for the first time. The results indicate that honey can postpone the peak concentration of GA in mouse blood, and this effect correlates well with fructose. As a representative of sweet foods, the result provides the valuable information that honey, or fructose, may act as sustained-releasing drugs in clinical scenarios; and that sweet foods may have some influences on drugs when taken together. View Full-Text

Keywords: glycyrrhizic acid; icELISA; pharmacokinetics; sweet foods glycyrrhizic acid; icELISA; pharmacokinetics; sweet foods





Author: Bingqian Jiang 1, Huihua Qu 2, Hui Kong 1, Yue Zhang 1, Shuchen Liu 1, Jinjun Cheng 1, Xin Yan 3 and Yan Zhao 1,*

Source: http://mdpi.com/



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