Carapanosins A–C from Seeds of Andiroba Carapa guianensis, Meliaceae and Their Effects on LPS-Activated NO ProductionReport as inadecuate


Carapanosins A–C from Seeds of Andiroba Carapa guianensis, Meliaceae and Their Effects on LPS-Activated NO Production


Carapanosins A–C from Seeds of Andiroba Carapa guianensis, Meliaceae and Their Effects on LPS-Activated NO Production - Download this document for free, or read online. Document in PDF available to download.

Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan





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Academic Editor: Derek J. McPhee

Abstract Two new phragmalin-type limonoids, Carapanosins A and B 1 and 2, and a new gedunin-type limonoid, Carapansin C 3, together with five known limonoids 4–8 were isolated from the oil of Carapa guianensis AUBLET Meliaceae seeds, a traditional medicine in Brazil and Latin American countries. Their structures were elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and HRFABMS. Compounds 1–8 were evaluated for their effects on the production of NO in LPS-activated mouse peritoneal macrophages. The NO inhibitory assay suggested that Compounds 3, 6, and 8 may be valuable as potential inhibitors of macrophage activation. View Full-Text

Keywords: Carapa guianensis; Meliaceae; seed oil; limonoid; Carapanosins A–C Carapa guianensis; Meliaceae; seed oil; limonoid; Carapanosins A–C





Author: Keiichiro Higuchi, Teppei Miyake, Shoko Ohmori, Yoshimi Tani, Katsuhiko Minoura, Takashi Kikuchi, Takeshi Yamada and Reiko Tanaka *

Source: http://mdpi.com/



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