Synthesis and Cytotoxicity of N-Substituted Dibenzoa,jxanthene-3,11-dicarboxamide DerivativesReport as inadecuate


Synthesis and Cytotoxicity of N-Substituted Dibenzoa,jxanthene-3,11-dicarboxamide Derivatives


Synthesis and Cytotoxicity of N-Substituted Dibenzoa,jxanthene-3,11-dicarboxamide Derivatives - Download this document for free, or read online. Document in PDF available to download.

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School of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040, China

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College of Pharmacy, Harbin Medical University, Harbin 150081, China

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College of Pharmacy, Harbin Medical University Daqing Campus, Daqing 163319, China





*

Author to whom correspondence should be addressed.



Academic Editor: Roman Dembinski

Abstract In order to study the structure-activity relationships of xanthene derivatives, four series of N-substituted 14-aryl-14H-dibenzoa,jxanthene-3,11-dicarboxamide derivatives were synthesized. The structures of all compounds were identified by 1H-NMR, HR-MS and IR spectra, in which compounds 6a–h were further identified by 13C-NMR spectra. The in vitro antitumor activity of the synthesized compounds was tested by MTT assay. Most of them displayed strong inhibitory activity on human hepatocellular carcinoma cell lines SK-HEP-1, HepG2 and SMMC-7721 cells and acute promyelocytic leukemia NB4 cells. Compounds 6c–6e exhibited significant inhibitory activity against NB4 cells with IC50 values of 0.52 μM and 0.76 μM, respectively, much lower than 5.31 μM of the positive control As2O3. View Full-Text

Keywords: synthesis design; cytotoxicity; dibenzoa,jxanthenes; NMR spectroscopy synthesis design; cytotoxicity; dibenzoa,jxanthenes; NMR spectroscopy





Author: Yongbin Song 1, Yihui Yang 2,* , Lijun Wu 2, Naiwei Dong 2, Shang Gao 2, Hongrui Ji 1, Xia Du 1, Bo Liu 1 and Guoyou Chen 3

Source: http://mdpi.com/



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