Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory AgentsReport as inadecuate


Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents


Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents - Download this document for free, or read online. Document in PDF available to download.

1

Department of Pharmaceutical Chemistry, Faculty of Pharmacy Girls, Al-Azhar University, Cairo 11754, Egypt

2

Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Giza 12622, Egypt

3

Pharmaceutical Chemistry Department, Drug Exploration and Development Chair DEDC, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

4

Pharmacology Department, National Research Centre, Dokki, Cairo 12622, Egypt





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract With the aim of developing novel anti-inflammatory scaffolds, a new series of pyrazole-substituted various nitrogenous heterocyclic ring systems at C-4 position were synthesized through different chemical reactions and validated by means of spectral and elemental data. The new obtained compounds were investigated for their anti-inflammatory activity using the carrageenan-induced paw edema standard technique and revealed that, compound 6b showed increased potency with % inhibition of edema 85.23 ± 1.92 and 85.78 ± 0.99, respectively, higher than the standard reference drugs indomethacin and celebrex 72.99% and 83.76%. Molecular modeling studies were initiated herein to validate the attained pharmacological data and provide understandable evidence for the observed anti-inflammatory behavior. View Full-Text

Keywords: 1,3-diaryl pyrazole derivatives; anti-inflammatory activity; synthesis 1,3-diaryl pyrazole derivatives; anti-inflammatory activity; synthesis





Author: Eman S. Nossier 1, Hoda H. Fahmy 2, Nagy M. Khalifa 2,3,* , Wafaa I. El-Eraky 4 and Marawan A. Baset 4

Source: http://mdpi.com/



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