2-{E-2-3E-2-Chloro-3-{2E-2-1,1-dimethyl-3-3-phenylpropyl-1,3-dihydro-2H-benzoeindol-2-ylidene-ethylidene}cyclohex-1-en-1-ylethenyl}-1,1-dimethyl-3-3-phenylpropyl-1H-benzoeindolium IodideReport as inadecuate


2-{E-2-3E-2-Chloro-3-{2E-2-1,1-dimethyl-3-3-phenylpropyl-1,3-dihydro-2H-benzoeindol-2-ylidene-ethylidene}cyclohex-1-en-1-ylethenyl}-1,1-dimethyl-3-3-phenylpropyl-1H-benzoeindolium Iodide


2-{E-2-3E-2-Chloro-3-{2E-2-1,1-dimethyl-3-3-phenylpropyl-1,3-dihydro-2H-benzoeindol-2-ylidene-ethylidene}cyclohex-1-en-1-ylethenyl}-1,1-dimethyl-3-3-phenylpropyl-1H-benzoeindolium Iodide - Download this document for free, or read online. Document in PDF available to download.

1

Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA

2

Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA

3

Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA





*

Author to whom correspondence should be addressed.



Abstract In four synthetic steps we successfully prepared a red-shifted heptamethine cyanine dye λmax = 825 nm in methanol that could be very useful for biochemists and bioanalytical chemists for probing lipophilic environments, including the hydrophobic pockets of enzymes. The heptamethine dye structure was characterized by various spectroscopic techniques including 1H-NMR, 13C-NMR and high-resolution accurate mass spectroscopy HRMS. We have also shown the hydrophobicity spectrally by varying methanol-water ratios and observing corresponding absorbance and fluorescence spectral changes. View Full-Text

Keywords: Hydrophobicity; carbocyanine; near-infrared; fluorescence; absorption; Vilsmeier-Haack reagent Hydrophobicity; carbocyanine; near-infrared; fluorescence; absorption; Vilsmeier-Haack reagent





Author: Eric A. Owens 1,2,3, Joseph G. Tawney 1 and Maged M. Henary 1,2,3,*

Source: http://mdpi.com/



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