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Chitooligosaccharide-2,5-anhydro-D-mannonic Acid


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Ingénierie des Matériaux Polymères IMP, UMR CNRS 5223, Université Claude Bernard Lyon 1, Université de Lyon, Villeurbanne F-69622, France





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Abstract Chitooligosaccharide with one 2,5-anhydro-D-mannofuranose unit at the reducing end COSamf was prepared by nitrous deamination of fully N-deacetylated chitosan. The oxidation of the amf-unit by chlorite sodium was achieved in high yield. The chemical structure of the targeted chitooligosaccharide-2,5-anhydro-D-mannonic acid with a degree of polymerization ~10 was fully characterized by NMR spectroscopy, MALDI-TOF mass spectrometry and size-exclusion chromatography. The success of this synthesis opens the way to a new generation of end-functionalized COS building blocks. View Full-Text

Keywords: chitosan; chitooligosaccharide-2,5-anhydro-D-mannofuranose; 2,5-anhydro-D-mannonic acid; nitrous deamination; oxidation chitosan; chitooligosaccharide-2,5-anhydro-D-mannofuranose; 2,5-anhydro-D-mannonic acid; nitrous deamination; oxidation





Author: Emil Salim, Daniela Ailincai and Stéphane Trombotto *

Source: http://mdpi.com/



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