Ethyl 2-hydroxy-2-phenyl-2-thiazol-2-ylacetateReport as inadecuate

Ethyl 2-hydroxy-2-phenyl-2-thiazol-2-ylacetate

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Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK


Syngenta CP R&D Chemistry, Jealotts Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK


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Abstract This short note describes the synthesis of the title compound through spontaneous aerobic oxidation of ethyl 2-phenyl-2-thiazol-2-ylacetate. Due to the prevalence of such functional motifs in biologically active substances, we believe the oxidation encountered highlights an important degradation pathway worthy of note. View Full-Text

Keywords: thiazole; oxidation product; heterocycles thiazole; oxidation product; heterocycles

Author: Carl J. Mallia 1, Lukas Englert 1, Gary C. Walter 2 and Ian R. Baxendale 1,*



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