Chemotaxonomic Characterization and in-Vitro Antimicrobial and Cytotoxic Activities of the Leaf Essential Oil of Curcuma longa Grown in Southern NigeriaReport as inadecuate




Chemotaxonomic Characterization and in-Vitro Antimicrobial and Cytotoxic Activities of the Leaf Essential Oil of Curcuma longa Grown in Southern Nigeria - Download this document for free, or read online. Document in PDF available to download.

1

Department of Chemistry, University of Uyo, Akwa Ibom State 520101, Nigeria

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Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA

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Department of Chemistry, University of Ibadan, Ibadan 200284, Nigeria





*

Author to whom correspondence should be addressed.



Academic Editors: Lutfun Nahar, Norazah Basar and Satyajit D. Sarker

Abstract Curcuma longa turmeric has been used in Chinese traditional medicine and Ayurvedic medicine for many years. Methods: The leaf essential oil of C. longa from southern Nigeria was obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry GC-MS. The essential oil was screened for in vitro antibacterial, antifungal, and cytotoxic activities. The major components in C. longa leaf oil were ar-turmerone 63.4%, α-turmerone 13.7%, and β-turmerone 12.6%. A cluster analysis has revealed this to be a new essential oil chemotype of C. longa. The leaf oil showed notable antibacterial activity to Bacillus cereus and Staphylococcus aureus, antifungal activity to Aspergillus niger, and cytotoxic activity to Hs 578T breast tumor and PC-3 prostate tumor cells. The ar-turmerone-rich leaf essential oil of C. longa from Nigeria has shown potent biological activity and therapeutic promise. View Full-Text

Keywords: Curcuma longa; essential oil composition; ar-turmerone; α-turmerone; β-turmerone; antimicrobial; cytotoxic Curcuma longa; essential oil composition; ar-turmerone; α-turmerone; β-turmerone; antimicrobial; cytotoxic





Author: Emmanuel E. Essien 1,* , Jennifer Schmidt Newby 2, Tameka M. Walker 2, William N. Setzer 2 and Olusegun Ekundayo 3

Source: http://mdpi.com/



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