Composition and Biological Activities of Murraya paniculata L. Jack Essential Oil from NepalReport as inadecuate




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1

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA

2

Department of Botany, Tribhuvan University, MMAMC, Biratnagar 56600, Nepal





*

Author to whom correspondence should be addressed.



Academic Editors: Lutfun Nahar, Norazah Basar and Satyajit D. Sarker

Abstract Murraya paniculata L. Jack, a small tropical evergreen shrub growing in Nepal, has numerous uses in traditional medicine for treatment of abdominal pain, diarrhea, stomach ache, headache, edema, thrombosis, and blood stasis. The present study investigated the chemical composition and bioactivities of the leaf essential oil from M. paniculata from Nepal. The essential oil from leaves was obtained by hydrodistillation and a detailed chemical analysis was conducted by gas chromatography-mass spectrometry GC-MS. The essential oil was screened for antimicrobial activity using the microbroth dilution test, for nematicidal activity against Caenorhabditis elegans, and for lethality against brine shrimp Artemia salina. A total of 76 volatile components were identified from the essential oil. The major components were methyl palmitate 11.1%, isospathulenol 9.4%, E,E-geranyl linalool 5.3%, benzyl benzoate 4.2%, selin-6-en-4-ol 4.0%, β-caryophyllene 4.0%, germacrene B 3.6%, germacrene D 3.4%, and γ-elemene 3.2%. The essential oil showed no antibacterial activity, marginal antifungal activity against Aspergillus niger MIC = 313 μg-mL, a moderate activity against A. salina LC50 = 41 μg-mL, and a good nematicidal activity against C. elegans LC50 = 37 μg-mL. View Full-Text

Keywords: Murraya paniculata; GC-MS; essential oil composition; hierarchical cluster analysis; antifungal; brine shrimp lethality; nematicidal Murraya paniculata; GC-MS; essential oil composition; hierarchical cluster analysis; antifungal; brine shrimp lethality; nematicidal





Author: Noura S. Dosoky 1, Prabodh Satyal 1, Tilak P. Gautam 2 and William N. Setzer 1,*

Source: http://mdpi.com/



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