Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatumReport as inadecuate




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1

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan

2

Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan

3

Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan

4

Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan





*

Authors to whom correspondence should be addressed.



Abstract In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A–C 1–3 as well as two known briaranes, briaexcavatolide U 4 and briaexcavatin L 5 were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV human cytomegalovirus activity of 1–5 and their cytotoxicity against selected cancer cell lines were evaluated. View Full-Text

Keywords: Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV





Author: Tsun-Tai Yeh 1, Shang-Kwei Wang 2,* , Chang-Feng Dai 3 and Chang-Yih Duh 1,4,*

Source: http://mdpi.com/



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