Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplexReport as inadecuate




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1

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan

2

Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan

3

National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan

4

Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan

5

Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan





*

Author to whom correspondence should be addressed.



Abstract Four new eunicellin-based diterpenes, simplexins P–S 1–4, and the known compound simplexin A 5, have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3–5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic. View Full-Text

Keywords: soft coral; eunicellin-based diterpenes; cytotoxicity; Klyxum simplex soft coral; eunicellin-based diterpenes; cytotoxicity; Klyxum simplex





Author: Shwu-Li Wu 1,2, Jui-Hsin Su 3,4, Chiung-Yao Huang 1, Chi-Jen Tai 1, Ping-Jyun Sung 3,4, Chih-Chung Liaw 1 and Jyh-Horng Sheu 1,5,*

Source: http://mdpi.com/



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