Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling ActivityReport as inadecuate




Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity - Download this document for free, or read online. Document in PDF available to download.

1

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China

2

China National Center for Biotechnology Development, Beijing 100036, China

3

National Museum of Natural History Naturalis, 2300 RA, Leiden 9515, The Netherlands

4

Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Duesseldorf 40225, Germany





*

Author to whom correspondence should be addressed.



Abstract Nine new compounds, namely sinularones A–I 1–9, characterized as cyclopentenone and butenolide-type analogues, were isolated from a soft coral Sinularia sp., together with a known butenolide 10. Their structures were elucidated by means of spectroscopic IR, MS, 1D and 2D NMR, CD analysis. The absolute configurations were determined on the basis of CD and specific rotation data in association with the computed electronic circular dichroism ECD by time dependent density functional theory TD DFT at 6-31+Gd,p-DFT B3LYP-6-31+Gd,p level. Compounds 1–2 and 7–10 showed potent antifouling activities against the barnacle Balanus amphitrite. View Full-Text

Keywords: soft coral; Sinularia sp.; sinularones A–I; structural elucidation; antifouling activity soft coral; Sinularia sp.; sinularones A–I; structural elucidation; antifouling activity





Author: Haiyan Shi 1, Shanjiang Yu 2, Dong Liu 1, Leen van Ofwegen 3, Peter Proksch 4 and Wenhan Lin 1,*

Source: http://mdpi.com/



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