New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.Report as inadecuate




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Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

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Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China





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Abstract Five new cembrane diterpenoids, named sinuflexibilins A–E 1–5, along with nine other known diterpenoids 6–14, have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. View Full-Text

Keywords: Sinularia sp.; cembrane diterpenoids; NF-κB inhibitor Sinularia sp.; cembrane diterpenoids; NF-κB inhibitor





Author: Bin Yang 1,2, Xuefeng Zhou 1,2, Hui Huang 1, Xian-Wen Yang 1,2, Juan Liu 1,2, Xiuping Lin 1,2, Xiubao Li 1, Yan Peng 1,2 and Yonghong Liu 1,2,*

Source: http://mdpi.com/



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