New Metabolites and Bioactive Chlorinated Benzophenone Derivatives Produced by a Marine-Derived Fungus Pestalotiopsis heterocornisReport as inadecuate


New Metabolites and Bioactive Chlorinated Benzophenone Derivatives Produced by a Marine-Derived Fungus Pestalotiopsis heterocornis


New Metabolites and Bioactive Chlorinated Benzophenone Derivatives Produced by a Marine-Derived Fungus Pestalotiopsis heterocornis - Download this document for free, or read online. Document in PDF available to download.

1

Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China

2

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

3

Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China

4

Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Shenyang 110016, China





*

Authors to whom correspondence should be addressed.



Academic Editor: Orazio Taglialatela-Scafati

Abstract Four new compounds, including two isocoumarins, pestaloisocoumarins A and B 1, 2, one sesquiterpenoid degradation, isopolisin B 4, and one furan derivative, pestalotiol A 5, together with one known isocoumarin, gamahorin 3, and three chlorinated benzophenone derivatives, pestalachloride B 6, pestalachloride E 7 and a mixture of pestalalactone atropisomers 8a-8b, were isolated from a culture of the fungus Pestalotiopsis heterocornis associated with sponge Phakellia fusca. These new chemical structures were established using NMR and MS spectroscopic data, as well as single-crystal X-ray crystallographic analysis and CD Cotton effects. All of the isolated compounds were evaluated for their antimicrobial and cytotoxic activities. Isocoumarins 1–3, showed antibacterial activities against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis with MIC values ranging from 25 to 100 μg-mL and weak antifungal activities. Chlorinated benzophenone derivatives 6–8 exhibited antibacterial activities against S. aureus and B. subtilis with MIC values ranging from 3.0 to 50 μg-mL and cytotoxicities against four human cancer cell lines with IC50 values of 6.8–87.8 μM. View Full-Text

Keywords: antibacterial activity; antifungal activity; cytotoxicity; isocoumarin; Pestalotiopsis heterocornis antibacterial activity; antifungal activity; cytotoxicity; isocoumarin; Pestalotiopsis heterocornis





Author: Hui Lei 1, Xiuping Lin 2, Li Han 1,* , Jian Ma 1, Qingjuan Ma 1, Jialiang Zhong 3, Yonghong Liu 2, Tiemin Sun 4, Jinhui Wang 4 and Xueshi Huang 1,*

Source: http://mdpi.com/



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