Chitin Oligosaccharide COS Reduces Antibiotics Dose and Prevents Antibiotics-Caused Side Effects in Adolescent Idiopathic Scoliosis AIS Patients with Spinal Fusion SurgeryReport as inadecuate


Chitin Oligosaccharide COS Reduces Antibiotics Dose and Prevents Antibiotics-Caused Side Effects in Adolescent Idiopathic Scoliosis AIS Patients with Spinal Fusion Surgery


Chitin Oligosaccharide COS Reduces Antibiotics Dose and Prevents Antibiotics-Caused Side Effects in Adolescent Idiopathic Scoliosis AIS Patients with Spinal Fusion Surgery - Download this document for free, or read online. Document in PDF available to download.

Department of Orthopedics, The Second Hospital of JiLin University, Changchun 130041, China





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Academic Editors: Hitoshi Sashiwa and David Harding

Abstract Antibiotics are always considered for surgical site infection SSI in adolescent idiopathic scoliosis AIS surgery. However, the use of antibiotics often causes the antibiotic resistance of pathogens and side effects. Thus, it is necessary to explore natural products as drug candidates. Chitin Oligosaccharide COS has anti-inflammation and anti-bacteria functions. The effects of COS on surgical infection in AIS surgery were investigated. A total of 312 AIS patients were evenly and randomly assigned into control group CG, each patient took one-gram alternative Azithromycin-Erythromycin-Cloxacillin-Aztreonam-Ceftazidime or combined daily, experiment group EG, each patient took 20 mg COS and half-dose antibiotics daily, and placebo group PG, each patient took 20 mg placebo and half-dose antibiotics daily. The average follow-up was one month, and infection severity and side effects were analyzed. The effects of COS on isolated pathogens were analyzed. SSI rates were 2%, 3% and 8% for spine wounds and 1%, 2% and 7% for iliac wound in CG, EG and PG p < 0.05, respectively. COS reduces the side effects caused by antibiotics p < 0.05. COS improved biochemical indexes and reduced the levels of interleukin IL-6 and tumor necrosis factor TNF alpha. COS reduced the antibiotics dose and antibiotics-caused side effects in AIS patients with spinal fusion surgery by improving antioxidant and anti-inflammatory activities. COS should be developed as potential adjuvant for antibiotics therapies. View Full-Text

Keywords: chitin oligosaccharide; antimicrobial prophylaxis; adolescent idiopathic scoliosis; spinal fusion chitin oligosaccharide; antimicrobial prophylaxis; adolescent idiopathic scoliosis; spinal fusion





Author: Yang Qu, Jinyu Xu, Haohan Zhou, Rongpeng Dong, Mingyang Kang and Jianwu Zhao *

Source: http://mdpi.com/



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