Metabolic Disorder in Chronic Obstructive Pulmonary Disease COPD Patients: Towards a Personalized Approach Using Marine Drug DerivativesReport as inadecuate


Metabolic Disorder in Chronic Obstructive Pulmonary Disease COPD Patients: Towards a Personalized Approach Using Marine Drug Derivatives


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1

Clinical and Molecular Epidemiology, IRCSS San Raffaele Pisana, Via di Valcannuta 247, I-00166 Rome, Italy

2

Department of Pulmonary Rehabilitation, IRCCS San Raffaele Pisana, Via della Pisana 235, I-00163 Rome, Italy

3

Scientific Direction, IRCSS San Raffaele Pisana, Via di Valcannuta 247, I-00166 Rome, Italy





*

Author to whom correspondence should be addressed.



Academic Editor: Peer B. Jacobson

Abstract Metabolic disorder has been frequently observed in chronic obstructive pulmonary disease COPD patients. However, the exact correlation between obesity, which is a complex metabolic disorder, and COPD remains controversial. The current study summarizes a variety of drugs from marine sources that have anti-obesity effects and proposed potential mechanisms by which lung function can be modulated with the anti-obesity activity. Considering the similar mechanism, such as inflammation, shared between obesity and COPD, the study suggests that marine derivatives that act on the adipose tissues to reduce inflammation may provide beneficial therapeutic effects in COPD subjects with high body mass index BMI. View Full-Text

Keywords: chronic obstructive pulmonary disease; comorbidities; management strategy; marine compound; metabolic disorder; inflammation; systems approaches chronic obstructive pulmonary disease; comorbidities; management strategy; marine compound; metabolic disorder; inflammation; systems approaches





Author: Palma Lamonaca 1, Giulia Prinzi 1, Aliaksei Kisialiou 1, Vittorio Cardaci 2, Massimo Fini 3 and Patrizia Russo 1,*

Source: http://mdpi.com/



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