Characterization and Potential Antitumor Activity of Polysaccharide from Gracilariopsis lemaneiformisReport as inadecuate


Characterization and Potential Antitumor Activity of Polysaccharide from Gracilariopsis lemaneiformis


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1

Key Laboratory of Marine Biotechnology of Zhejiang Province, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China

2

School of Biomedical Engineering, Bio-ID Research Center, Shanghai Jiao Tong University, Shanghai 200240, China

3

College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China

4

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China





*

Author to whom correspondence should be addressed.



Academic Editors: Yu-Dong Zhou and Dale G. Nagle

Abstract Substances with valuable antitumor properties have been identified in many marine algae, including an edible polysaccharide from the marine alga Gracilariopsis lemaneiformis PGL. We previously reported transcriptome profiling data showing that PGL induced transcriptional alterations generate anti-lung cancer activity. To identify how PGL is detrimental to tumors, we purified PGL to characterize its chemical composition, molecular weight, and sugar and protein content and investigated its antitumor activity. We demonstrated that PGL exerted its antitumor activities by modulating cell viability, morphology, apoptosis, and the apoptosis-related Fas-FasL signaling pathway in the human lung cancer cell line A549, the gastric cancer cell line MKN28, and the mouse melanoma cell line B16. Our data provide the first evidence that PGL inhibits cell proliferation by inducing apoptosis, which is largely mediated by Fas-FasL in cancer cells, suggesting that PGL might be a novel therapeutic agent against cancer. View Full-Text

Keywords: polysaccharide; Gracilariopsis lemaneiformis; antitumor activity; Fas-FasL pathway; cell proliferation; apoptosis polysaccharide; Gracilariopsis lemaneiformis; antitumor activity; Fas-FasL pathway; cell proliferation; apoptosis





Author: Yani Kang 1,2, Zhi-Jiang Wang 3, Dongsheng Xie 4, Xue Sun 1, Wenge Yang 1, Xiaodong Zhao 2 and Nianjun Xu 1,*

Source: http://mdpi.com/



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