Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II DiabetesReport as inadecuate


Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes


Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes - Download this document for free, or read online. Document in PDF available to download.

1

Department of Food Science, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung 202, Taiwan

2

Center of Excellence for the Oceans, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung 202, Taiwan

3

Department of Bioscience and Biotechnology, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung 202, Taiwan





*

Author to whom correspondence should be addressed.



Academic Editor: Keith B. Glaser

Abstract The combined effects of low-molecular-weight fucoidan LMF and fucoxanthin Fx in terms of antihyperglycemic, antihyperlipidemic, and hepatoprotective activities were investigated in a mouse model of type II diabetes. The intake of LMF, Fx, and LMF + Fx lowered the blood sugar and fasting blood sugar levels, and increased serum adiponectin levels. The significant decrease in urinary sugar was only observed in LMF + Fx supplementation. LMF and Fx had ameliorating effects on the hepatic tissue of db-db mice by increasing hepatic glycogen and antioxidative enzymes, and LMF was more effective than Fx at improving hepatic glucose metabolism. As for glucose and lipid metabolism in the adipose tissue, the expression of insulin receptor substrate IRS-1, glucose transporter GLUT, peroxisome proliferator-activated receptor gamma PPARγ, and uncoupling protein UCP-1 mRNAs in the adipose tissue of diabetic mice was significantly upregulated by Fx and LMF + Fx, and levels of inflammatory adipocytokines, such as adiponectin, tumor necrosis factor-α TNF-α, and interleukin-6 IL-6, were significantly modulated only by LMF + Fx supplementation. The efficacy of LMF + Fx supplementation on the decrease in urinary sugar and on glucose and lipid metabolism in the white adipose tissue of db-db mice was better than that of Fx or LMF alone, indicating the occurrence of a synergistic effect of LMF and Fx. View Full-Text

Keywords: type II diabetes; db-db mice; brown algae; fucoidan; fucoxanthin; glucose homeostasis; lipid metabolism; live function type II diabetes; db-db mice; brown algae; fucoidan; fucoxanthin; glucose homeostasis; lipid metabolism; live function





Author: Hong-Ting Victor Lin 1,2, Yu-Chi Tsou 3, Yu-Ting Chen 3, Wen-Jung Lu 1 and Pai-An Hwang 3,*

Source: http://mdpi.com/



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