Laucysteinamide A, a Hybrid PKS-NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillataReport as inadecuate


Laucysteinamide A, a Hybrid PKS-NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata


Laucysteinamide A, a Hybrid PKS-NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata - Download this document for free, or read online. Document in PDF available to download.

1

Department of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA

2

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA

3

Department of Biological Sciences, Florida International University, Miami, FL 33199, USA

4

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA





*

Author to whom correspondence should be addressed.



Academic Editors: Yu-Dong Zhou and Dale G. Nagle

Abstract A bioactivity guided study of a cf. Caldora penicillata species, collected during a 2013 expedition to the Pacific island of Saipan, Northern Mariana Islands a commonwealth of the USA, led to the isolation of a new thiazoline-containing alkaloid, laucysteinamide A 1. Laucysteinamide A is a new monomeric analogue of the marine cyanobacterial metabolite, somocystinamide A 2, a disulfide-bonded dimeric compound that was isolated previously from a Fijian marine cyanobacterium. The structure and absolute configuration of laucysteinamide A 1 was determined by a detailed analysis of its NMR, MS, and CD spectra. In addition, the highly bioactive lipid, curacin D 3, was also found to be present in this cyanobacterial extract. The latter compound was responsible for the potent cytotoxicity of this extract to H-460 human non-small cell lung cancer cells in vitro. View Full-Text

Keywords: laucysteinamide A; cyanobacteria; blue-green alga; thiazoline alkaloid; cytotoxicity laucysteinamide A; cyanobacteria; blue-green alga; thiazoline alkaloid; cytotoxicity





Author: Chen Zhang 1, C. Benjamin Naman 2, Niclas Engene 3 and William H. Gerwick 2,4,*

Source: http://mdpi.com/



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