Bioresponsive Materials for Drug Delivery Based on Carboxymethyl Chitosan-Polyγ-Glutamic Acid Composite MicroparticlesReport as inadecuate


Bioresponsive Materials for Drug Delivery Based on Carboxymethyl Chitosan-Polyγ-Glutamic Acid Composite Microparticles


Bioresponsive Materials for Drug Delivery Based on Carboxymethyl Chitosan-Polyγ-Glutamic Acid Composite Microparticles - Download this document for free, or read online. Document in PDF available to download.

School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China



These authors contributed equally to this work.





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Academic Editors: Hitoshi Sashiwa and David Harding

Abstract Carboxymethyl chitosan CMCS microparticles are a potential candidate for hemostatic wound dressing. However, its low swelling property limits its hemostatic performance. Polyγ-glutamic acid PGA is a natural polymer with excellent hydrophilicity. In the current study, a novel CMCS-PGA composite microparticles with a dual-network structure was prepared by the emulsification-internal gelation method. The structure and thermal stability of the composite were determined by Fourier transform infrared spectroscopy FTIR, X-ray powder diffraction XRD, scanning electron microscope SEM, X-ray photoelectron spectroscopy XPS, and thermogravimetric analysis TGA. The effects of preparation conditions on the swelling behavior of the composite were investigated. The results indicate that the swelling property of CMCS-PGA composite microparticles is pH sensitive. Levofloxacin LFX was immobilized in the composite microparticles as a model drug to evaluate the drug delivery performance of the composite. The release kinetics of LFX from the composite microparticles with different structures was determined. The results suggest that the CMCS-PGA composite microparticles are an excellent candidate carrier for drug delivery. View Full-Text

Keywords: carboxymethyl chitosan; polyγ-glutamic acid; microparticle; drug release carboxymethyl chitosan; polyγ-glutamic acid; microparticle; drug release





Author: Xiaoting Yan †, Zongrui Tong †, Yu Chen * , Yanghe Mo, Huaiyu Feng, Peng Li, Xiaosai Qu and Shaohua Jin

Source: http://mdpi.com/



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