Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. TA07-1Report as inadecuate


Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. TA07-1


Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. TA07-1 - Download this document for free, or read online. Document in PDF available to download.

1

Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, the Ministry of Education of China, Qingdao 266003, China

2

Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China

3

Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao 266003, China





*

Author to whom correspondence should be addressed.



Academic Editor: Peer B. Jacobson

Abstract Three new diphenyl ether derivatives—phomaethers A–C 1–3 and five known compounds—including a diphenyl ether analog, 2,3′-dihydroxy-4-methoxy-5′,6-dimethyl diphenyl ether 4; and four isocoumarin derivatives, diaportinol 5, desmethyldiaportinol 6, citreoisocoumarinol 7, and citreoisocoumarin 8—were isolated from a gorgonian-derived fungus Phoma sp. TA07-1. Their structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by acid hydrolysis reactions. It was the first report to discover the diphenyl glycoside derivatives from coral-derived fungi. Compounds 1, 3, and 4 showed selective strong antibacterial activity against five pathogenic bacteria with the minimum inhibiting concentration MIC values and minimum bactericidal concentration MBC values between 0.156 and 10.0 μM. View Full-Text

Keywords: gorgonian-derived fungus; Phoma sp.; diphenyl ether; isocoumarin; antibacterial activity gorgonian-derived fungus; Phoma sp.; diphenyl ether; isocoumarin; antibacterial activity





Author: Ting Shi 1,2, Jun Qi 1,2, Chang-Lun Shao 1,2, Dong-Lin Zhao 1,2, Xue-Mei Hou 1,2 and Chang-Yun Wang 1,2,3,*

Source: http://mdpi.com/



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