Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornisReport as inadecuate


Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis


Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis - Download this document for free, or read online. Document in PDF available to download.

1

Department of Chemistry, University of the West Indies, Mona Campus, St. Andrew JMAAW15, Jamaica

2

Natural Products Institute, University of the West Indies, Mona Campus, St. Andrew JMAAW15, Jamaica





*

Author to whom correspondence should be addressed.



Academic Editor: Orazio Taglialatela-Scafati

Abstract The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane 1 and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane 2 and the previously isolated dolastane 4R,9S,14S-4,9,14-trihydroxydolast-115,7-diene 3 as a major diterpene constituent. The structures of the new compounds were elucidated by extensive spectroscopic analyses. Compounds 1–3 were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29. The results revealed that the dolastane diterpenes 1–3 displayed moderate, concentration dependent, cytotoxicity. View Full-Text

Keywords: dolastane; diterpenes; Canistrocarpus cervicornis dolastane; diterpenes; Canistrocarpus cervicornis





Author: Sanjay Campbell 1, JeAnn Murray 2, Rupika Delgoda 2 and Winklet Gallimore 1,*

Source: http://mdpi.com/



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