The Missing Piece in Biosynthesis of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carteraeReport as inadecuate


The Missing Piece in Biosynthesis of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carterae


The Missing Piece in Biosynthesis of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carterae - Download this document for free, or read online. Document in PDF available to download.

Institute of Biomolecular Chemistry, National Research Council CNR, Pozzuoli 80078, Naples, Italy





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Academic Editor: Paul Long

Abstract Two new members of the amphidinol family, amphidinol A 1 and its 7-sulfate derivative amphidinol B 2, were isolated from a strain of Amphidinium carterae of Lake Fusaro, near Naples Italy, and chemically identified by spectroscopic and spectrometric methods. Amphidinol A showed antifungal activity against Candida albicans MIC = 19 µg-mL. Biosynthetic experiments with stable isotope-labelled acetate allowed defining the elongation process in 1. For the first time the use of glycolate as a starter unit in the polyketide biosynthesis of amphidinol metabolites was unambiguously demonstrated. View Full-Text

Keywords: amphidinol; amphidinol-related polyketide; Amphidinium; dinoflagellate, glycolate; polyketide biosynthesis; PKS; antifungal polyketide; Candida albicans; SHAM amphidinol; amphidinol-related polyketide; Amphidinium; dinoflagellate, glycolate; polyketide biosynthesis; PKS; antifungal polyketide; Candida albicans; SHAM





Author: Adele Cutignano * , Genoveffa Nuzzo, Angela Sardo and Angelo Fontana

Source: http://mdpi.com/



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