Preimplantation Genetic Diagnosis: Prenatal Testing for Embryos Finally Achieving Its PotentialReport as inadecuate




Preimplantation Genetic Diagnosis: Prenatal Testing for Embryos Finally Achieving Its Potential - Download this document for free, or read online. Document in PDF available to download.

1

Division of Reproductive Genetics, Genetics & IVF Institute, 3015 Williams Drive, Fairfax, VA 22031, USA

2

Departments of Obstetrics and Gynecology, Pediatrics and Human Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA





Abstract Preimplantation genetic diagnosis was developed nearly a quarter-century ago as an alternative form of prenatal diagnosis that is carried out on embryos. Initially offered for diagnosis in couples at-risk for single gene genetic disorders, such as cystic fibrosis, spinal muscular atrophy and Huntington disease, preimplantation genetic diagnosis PGD has most frequently been employed in assisted reproduction for detection of chromosome aneuploidy from advancing maternal age or structural chromosome rearrangements. Major improvements have been seen in PGD analysis with movement away from older, less effective technologies, such as fluorescence in situ hybridization FISH, to newer molecular tools, such as DNA microarrays and next generation sequencing. Improved results have also started to be seen with decreasing use of Day 3 blastomere biopsy in favor of polar body or Day 5 trophectoderm biopsy. Discussions regarding the scientific, ethical, legal and social issues surrounding the use of sequence data from embryo biopsy have begun and must continue to avoid concern regarding eugenic or inappropriate use of this technology. View Full-Text

Keywords: preimplantation genetic diagnosis; chromosomal microarray; embryo biopsy; next generation sequencing; inherited genetic disorders preimplantation genetic diagnosis; chromosomal microarray; embryo biopsy; next generation sequencing; inherited genetic disorders





Author: Harvey J. Stern 1,2

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents