Pediatric Bipolar Disorder: Subtype Trend and Impact of Behavioral ComorbiditiesReport as inadecuate




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1

Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore MD-21201, USA

2

Departments of Psychiatry and Pediatrics, Johns Hopkins Medical Institutions, Baltimore MD-21287, USA





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Author to whom correspondence should be addressed.



Abstract The diagnosis of pediatric bipolar disorder PBD has increased dramatically in community-treated youth in the past 20 years. No previous study has assessed the trend in PBD subtype diagnoses or the impact of clinician-reported behavioral comorbidities BC on psychotropic medication prescribing patterns. This study aims: 1 to characterize national trends in PBD visits in relation to PBD subtypes; and 2 to assess differences in socio-demographic PBD subtype diagnostic patterns and psychotropic medications prescribed in PBD visits with and without behavioral comorbidities w-w-o BC. PBD visits for 1999–2010 from the National Ambulatory Medical Care Survey NAMCS data were assessed using population-weighted chi-square and logistic regression analyses. While PBD visit rates were stable across 12 years, the proportional shift of subtype diagnosis from Bipolar I 89.0% in 1999–2002 to Bipolar Not Otherwise Specified NOS 74.1% in 2007–2010 was notable. Compared with PBD without behavioral comorbidities w-o BC, PBD visits w-BC had greater proportions of the bipolar-NOS subtype, more males, 2–14-year-olds, and more publicly-insured visits. The prescription of antipsychotics 60% vs. 61% was common in PBD visits regardless of the presence of behavioral comorbidities. Stimulants were the predominant class prescribed for PBD visits with BC 67.8% vs. 9.4%. Antidepressants were significantly greater in PBD visits without BC 41.6% vs. 21.0%. Overall one-third of PBD youth visits were prescribed antipsychotics concomitant with other psychotropic classes. Behavioral conditions accompanying PBD visits were prominent, suggesting the need for monitoring and evaluating the outcomes of complex medication regimens in community populations. View Full-Text

Keywords: pediatric bipolar disorder; behavioral comorbidities; psychotropic medication; antipsychotics; stimulants; antidepressants pediatric bipolar disorder; behavioral comorbidities; psychotropic medication; antipsychotics; stimulants; antidepressants





Author: Thiyagu Rajakannan 1, Julie M. Zito 1,* , Mehmet Burcu 1 and Daniel J. Safer 2

Source: http://mdpi.com/



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