Microarray Technology for the Diagnosis of Fetal Chromosomal Aberrations: Which Platform Should We UseReport as inadecuate




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1

NE Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, 37 Queen Square, London WC1N 3BH, UK

2

UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

3

University College Hospital NHS Foundation Trust, London NW1 2PG, UK

4

Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract The advantage of microarray array over conventional karyotype for the diagnosis of fetal pathogenic chromosomal anomalies has prompted the use of microarrays in prenatal diagnostics. In this review we compare the performance of different array platforms BAC, oligonucleotide CGH, SNP and designs targeted, whole genome, whole genome, and targeted, custom and discuss their advantages and disadvantages in relation to prenatal testing. We also discuss the factors to consider when implementing a microarray testing service for the diagnosis of fetal chromosomal aberrations. View Full-Text

Keywords: prenatal microarray; implementation; BAC; SNP prenatal microarray; implementation; BAC; SNP





Author: Evangelia Karampetsou 1,†, Deborah Morrogh 1,† and Lyn Chitty 2,3,4,†,*

Source: http://mdpi.com/



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