Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADHReport as inadecuate




Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADH - Download this document for free, or read online. Document in PDF available to download.

1

Departments of Internal Medicine, Erasmus University Hospital, Route de Lennik, 808, Brussels B-1070, Belgium

2

Departments of Nephrology, Erasmus University Hospital, Brussels B-1070, Belgium

3

Department of Internal Medicine, Bracops Hospital, Brussels B-1070, Belgium

4

Department of Internal Medicine, Jolimont-Tubize Hospital, Tubize 1480, Belgium





*

Author to whom correspondence should be addressed.



Abstract Oral urea has been used in the past to treat various diseases like gastric ulcers, liver metastases, sickle cell disease, heart failure, brain oedema, glaucoma, Meniere disease, etc. We have demonstrated for years, the efficacy of urea to treat euvolemic SIADH or hypervolemic hyponatremia. We briefly describe the indications of urea use in symptomatic and paucisymptomatic hyponatremic patients. Urea is a non-toxic, cheap product, and protects against osmotic demyelinating syndrome ODS in experimental studies. Prospective studies showing the benefit to treat mild chronic hyponatremia due to SIADH and comparing water restriction, urea, high ceiling diuretics, and antivasopressin antagonist antagonist should be done. View Full-Text

Keywords: hyponatremia; urea; V2 antagonist; ODS; SIADH; high ceiling diuretics hyponatremia; urea; V2 antagonist; ODS; SIADH; high ceiling diuretics





Author: Guy Decaux 1,* , Fabrice Gankam Kengne 2, Bruno Couturier 1, Frédéric Vandergheynst 1, Wim Musch 3 and Alain Soupart 1,4

Source: http://mdpi.com/



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