Opportunities and Limitations of Modelling Alzheimer’s Disease with Induced Pluripotent Stem CellsReport as inadecuate




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Stem Cell Engineering Group, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia 4072, Australia





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Abstract Reprogramming of somatic cells into induced pluripotent stem cells iPSCs has opened the way for patient-specific disease modelling. Following their differentiation into neuronal cell types, iPSC have enabled the investigation of human neurodegenerative diseases, such as Alzheimer’s disease AD. While human iPSCs certainly provide great opportunities to repeatedly interrogate specific human brain cell types of individuals with familial and sporadic forms of the disease, the complex aetiology and timescale over which AD develops in humans poses particular challenges to iPSC-based AD models. Here, we discuss the current state-of-play in the context of these and other iPSC model-related challenges and elaborate on likely future developments in this field of research. View Full-Text

Keywords: induced pluripotent stem cells; Alzheimer’s disease; disease modelling; reprogramming induced pluripotent stem cells; Alzheimer’s disease; disease modelling; reprogramming





Author: Dmitry A. Ovchinnikov and Ernst J. Wolvetang *

Source: http://mdpi.com/



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