Biochemistry of Bacterial Multidrug Efflux PumpsReport as inadecuate




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1

QC Laboratory, Post Harvest Technology Department, Central Institute of Fisheries Education CIFE, Versova, Mumbai 400061 India

2

Biology Department, Eastern New Mexico University, Portales New Mexico, 88130, USA





*

Author to whom correspondence should be addressed.



Abstract Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mechanism for bacterial pathogen drug resistance. Therefore, because of their overwhelming presence in bacterial pathogens, these active multi-drug efflux mechanisms remain a major area of intense study, so that ultimately measures may be discovered to inhibit these active multi-drug efflux pumps. View Full-Text

Keywords: efflux pump; antibiotic resistance; MFS; antiporter; Tet; Qac efflux pump; antibiotic resistance; MFS; antiporter; Tet; Qac





Author: Sanath Kumar 1 and Manuel F. Varela 2,*

Source: http://mdpi.com/



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