Study on the Immunomodulation Effect of Isodon japonicus Extract via Splenocyte Function and NK Anti-Tumor ActivityReport as inadecuate




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1

Department of Agrofood Resources, National Academy of Agricultural Science, RDA, Suwon 441-853, Korea

2

Department of Biotechnology & Bioengineering, Sungkyunkwan University, Suwon 440-746, Korea





*

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Abstract Here we investigated the potential immune-enhancing activity of Isodon japonicus on murine splenocyte and natural-killer NK cells in vitro. The ethanol extract of I. japonicus significantly enhanced the proliferation of splenocyte and induced the significant enhancement of NK cells’ activity against tumor cells YAC-1. In addition, I. japonicus increased the production of interferon IFN-γ and tumor necrosis factor TNF-α, suggesting that the increase in NK cell cytotoxicity could be due to the enhancement of the NK cell production of both cytokines. Taken together, I. japonicus extract inhibited the growth of human leukemia cells K562 by 74%. Our observation indicated that the anti-tumor effects of I. japonicus may be attributed to its ability to serve as a stimulant of NK anti-tumor activity. In addition, our results support the development of functional food studies on I. japonicus. View Full-Text

Keywords: Isodon japonicus; splenocyte; natural killer cell; cytokine Isodon japonicus; splenocyte; natural killer cell; cytokine





Author: Yu-Jin Hwang 1,2, Jaehyun Kim 1, Dong-Sik Park 1 and Kyung-A Hwang 1,*

Source: http://mdpi.com/



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