Nano Size Effects of TiO2 Nanotube Array on the Glioma Cells BehaviorReport as inadecuate




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1

Liaoning Provincial Universities Key Laboratory of Boron Resource Ecological Utilization Technology and Boron Materials, Northeastern University, No.11, Lane 3, Wenhua Road, Heping District, Shenyang 110819, China

2

Departments of Neurosurgery, The First Affiliated Hospital of China Medical University, 155 Nanjingbei Street, Heping District, Shenyang 110001, China



These authors contributed equally to this work.





*

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Abstract In order to investigate the interplay between the cells and TiO2 nanotube array, and to explore the ability of cells to sense the size change in nano-environment, we reported on the behavior of glioma C6 cells on nanotube array coatings in terms of proliferation and apoptosis. The behavior of glioma C6 cells was obviously size-dependent on the coatings; the caliber with 15 nm diameter provided effective spacing to improve the cells proliferation and enhanced the cellular activities. C6 cells’ biological behaviors showed many similar tendencies to many phorocytes; the matching degree of geometry between nanotube and integrin defined that a spacing of 15 nm was optimal for inducing signals to nucleus, which results in achieving maximum activity of glioma cells. In addition, the immune behavior of cells was studied, a variety of inflammatory mediator’s gene expression levels were controlled by the nanoscale dimension, the expressions of IL-6 and IL-10 were higher on 30 nm than on 15 nm nanotube. View Full-Text

Keywords: nanotube; glioma cells; proliferation; inflammatory mediator’s gene; signal channel nanotube; glioma cells; proliferation; inflammatory mediator’s gene; signal channel





Author: He Yang 1,†, Xiaofei Qin 2,†, Ang Tian 2,* , Dongyong Zhang 2, Xiangxin Xue 1 and Anhua Wu 2,*

Source: http://mdpi.com/



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