Prevention of Carcinogenesis and Development of Gastric and Colon Cancers by 2-Aminophenoxazine-3-one Phx-3: Direct and Indirect Anti-Cancer Activity of Phx-3Report as inadecuate




Prevention of Carcinogenesis and Development of Gastric and Colon Cancers by 2-Aminophenoxazine-3-one Phx-3: Direct and Indirect Anti-Cancer Activity of Phx-3 - Download this document for free, or read online. Document in PDF available to download.

1

Department of Biochemistry, Tokyo Medical University, 6-1-1 Shinjuku, Tokyo 160-8402, Japan

2

Fourth Department of Surgery, Tokyo Medical University, Ibaragi Medical Center, 3-20-1 Chuo, Ami, Inashiki, Ibaraki 300-0395, Japan





*

Author to whom correspondence should be addressed.



Abstract 2-Aminophenoxazine-3-one Phx-3, an oxidative phenoxazine, exerts strong anticancer effects on various cancer cell lines originating from different organs, in vitro. This article reviews new aspects for the prevention of carcinogenesis and development of gastric and colon cancers by Phx-3, based on the strong anticancer effects of Phx-3 on gastric and colon cancer cell lines direct anticancer effects of Phx-3 for preventing development of cancer, the bacteriocidal effects of Phx-3 against Helicobacter pylori associated with carcinogenesis of gastric cancer indirect anticancer effects for preventing carcinogenesis of gastric cancer, and the proapoptotic activity of Phx-3 against human neutrophils involved in the incidence of ulcerative colitis associated with a high colon cancer risk indirect anticancer effects for preventing carcinogenesis of colon cancer. View Full-Text

Keywords: Phx-3; gastric and colon cancers; apoptosis; neutrophils Phx-3; gastric and colon cancers; apoptosis; neutrophils





Author: Akio Tomoda 1,* , Keisuke Miyazawa 1 and Takafumi Tabuchi 2

Source: http://mdpi.com/



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