Maternal High Folic Acid Supplement Promotes Glucose Intolerance and Insulin Resistance in Male Mouse Offspring Fed a High-Fat DietReport as inadecuate




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1

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150086, China

2

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China





*

Author to whom correspondence should be addressed.



Abstract Maternal nutrition may influence metabolic profiles in offspring. We aimed to investigate the effect of maternal folic acid supplement on glucose metabolism in mouse offspring fed a high-fat diet HFD. Sixty C57BL-6 female mice were randomly assigned into three dietary groups and fed the AIN-93G diet containing 2 control, 5 recommended folic acid supplement, RFolS or 40 high folic acid supplement, HFolS mg folic acid-kg of diet. All male offspring were fed HFD for eight weeks. Physiological, biochemical and genetic variables were measured. Before HFD feeding, developmental variables and metabolic profiles were comparable among each offspring group. However, after eight weeks of HFD feeding, the offspring of HFolS dams Off-HFolS were more vulnerable to suffer from obesity p = 0.009, glucose intolerance p < 0.001 and insulin resistance p < 0.001, compared with the controls. Off-HFolS had reduced serum adiponectin concentration, accompanied with decreased adiponectin mRNA level but increased global DNA methylation level in white adipose tissue. In conclusion, our results suggest maternal HFolS exacerbates the detrimental effect of HFD on glucose intolerance and insulin resistance in male offspring, implying that HFolS during pregnancy should be adopted cautiously in the general population of pregnant women to avoid potential deleterious effect on the metabolic diseases in their offspring. View Full-Text

Keywords: folate; epigenetics; metabolic syndrome; gestational nutrition supplement folate; epigenetics; metabolic syndrome; gestational nutrition supplement





Author: Yifan Huang 1, Yonghan He 2, Xiaowei Sun 1, Yujie He 1, Ying Li 1 and Changhao Sun 1,*

Source: http://mdpi.com/



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