Twist-1 Up-Regulation in Carcinoma Correlates to Poor SurvivalReport as inadecuate




Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival - Download this document for free, or read online. Document in PDF available to download.

1

Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, No. 270 Dong An Road, Shanghai 200032, China

2

Department of Oncology, Shanghai Medical College, Fudan University, No. 270 Dong An Road, Shanghai 200032, China

3

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, No. 270 Dong An Road, Shanghai 200032, China

4

Department Oral & Maxillofacial Surgery, College and Hospital of Stomatology, Xian Jiao Tong University, No. 98 Xiwu Road, Xian 710004, China



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract Epithelial-to-mesenchymal transition EMT facilitates tumor metastasis. Twist is a basic helix-loop-helix protein that modulates many target genes through E-box-responsive elements. There are two twist-like proteins, Twist-1 and Twist-2, sharing high structural homology in mammals. Twist-1 was found to be a key factor in the promotion of metastasis of cancer cells, and is known to induce EMT. Twist-1 participation in carcinoma progression and metastasis has been reported in a variety of tumors. However, controversy exists concerning the correlation between Twist-1 and prognostic value with respect to carcinoma. A systematic review and meta-analysis were performed to determine whether the expression of Twist-1 was associated with the prognosis of carcinoma patients. This analysis included 17 studies: four studies evaluated lung cancer, three evaluated head and neck cancer, two evaluated breast cancer, two evaluated esophageal cancer, two evaluated liver cancer and one each evaluated osteosarcoma, bladder, cervical and ovarian cancer. A total of 2006 patients were enrolled in these studies, and the median trial sample size was 118 patients. Twist-1 expression was associated with worse overall survival OS at both 3 years hazard ratio -HR- for death = 2.13, 95% CI = 1.86 to 2.45, p < 0.001 and 5 years HR for death = 2.01, 95% CI = 1.76 to 2.29, p < 0.001. Expression of Twist-1 is associated with worse survival in carcinoma. View Full-Text

Keywords: Twist-1; immunohistochemistry; tumor; prognosis; meta-analysis Twist-1; immunohistochemistry; tumor; prognosis; meta-analysis





Author: Alimujiang Wushou 1,2,†, Jing Hou 2,3,†, Ya-Jun Zhao 4,† and Zhi-Ming Shao 1,2,*

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents