A Genetic Polymorphism in RBP4 Is Associated with Coronary Artery DiseaseReport as inadecuate




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1

Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China

2

National Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, Chengdu 610041, China



These authors contributed equally to this work.





*

Authors to whom correspondence should be addressed.



Abstract Insulin resistance and obesity is influenced by the retinol binding protein 4 RBP4 adipokine. This study aims to determine if genetic polymorphisms in RBP4 are associated with the risk of coronary artery disease CAD in Chinese patients. RBP4 polymorphisms were analyzed by high resolution melting HRM analysis in a case-control study of 392 unrelated CAD patients and 368 controls from China. The Gensini score was used to determine the severity of CAD. The genotypic and allelic frequencies of RBP4 single-nucleotide polymorphisms were evaluated for associations with CAD and severity of disease. The A allele frequency was significantly higher in CAD case groups compared to control groups 16.7% vs. 8.8% at the RBP4 rs7094671 locus. Compared to the G allele, this allele was associated with a higher risk of CAD OR = 2.07 1.50–2.84. Polymorphisms at rs7094671 were found to associate with CAD using either a dominant or recessive model OR, 95% CI: 1.97, 1.38–2.81; 3.81, 1.53–9.51, respectively. Adjusting for sex, history of smoking, serum TC, TG, LDL-c, and HDL-c, the risk of CAD for carriers remained significantly higher in both dominant and recessive models OR, 95% CI: 1.68, 1.12–2.51; 2.74, 1.00–7.52, respectively. However, this SNP was not significantly associated with severity of CAD using angiographic scores in multivariable linear regression models p = 0.373. The RBP4 rs7094671 SNP is associated with CAD; however, our results do not indicate that this locus is associated with clinical severity of CAD or the extent of coronary lesions. View Full-Text

Keywords: RBP4; polymorphism; SNP; coronary artery disease CAD RBP4; polymorphism; SNP; coronary artery disease CAD





Author: Ke Wan 1,†, Jianxun Zhao 1,†, Ying Deng 2, Xi Chen 1, Qing Zhang 1, Zhi Zeng 1, Li Zhang 1,* and Yucheng Chen 1,*

Source: http://mdpi.com/



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