Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery DiseaseReport as inadecuate




Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease - Download this document for free, or read online. Document in PDF available to download.

1

Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei 23142, Taiwan

2

Department of Life Science, Chinese Culture University, Taipei 11114, Taiwan

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The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 33305, Taiwan

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The Division of Cardiology, Department of Internal Medicine and Cardiovascular Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei 23142, Taiwan

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Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taipei 33305, Taiwan

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School of Medicine, Tzu Chi University, Hualien 97071, Taiwan





*

Author to whom correspondence should be addressed.



Abstract YKL-40, a pleotropic cytokine, is emerging as a risk factor and a prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical and biochemical correlates of circulating YKL-40 level and, by combining it with CHI3L1 gene variants, with the risk and long-term mortality of peripheral artery disease PAD. Plasma YKL-40 concentrations were measured in 612 Taiwanese individuals who had no clinically overt systemic disease. Clinical parameters, CHI3L1 gene promoter variants and 18 biomarker levels were analyzed. Eighty-six PAD patients were further enrolled for analysis. Significant associations were found between CHI3L1 genotypes-haplotypes and YKL-40 levels for the health examination subjects smallest p = 8.36 × 10−7 for rs4950928 and smallest p = 1.72 × 10−10 for haplotype TGG and also for PAD patients. For the health examination subjects, circulating YKL-40 level, but not CHI3L1 gene variants, were positively associated with age, smoking, and circulating levels of triglyceride, lipocalin 2 and multiple inflammatory biomarkers and negatively associated with low-density-lipoprotein cholesterol levels. Circulating YKL-40 level is also significantly associated with the risk of PAD p = 3.3 × 10−23. Circulating YKL40 level, but not CHI3L1 gene promoter variants, is associated with the risk of PAD in Taiwanese. The association of YKL-40 levels with multiple quantitative traits relating to the risk of PAD may provide a molecular basis linking YKL-40 to atherosclerotic cardiovascular disease. View Full-Text

Keywords: circulating YKL-40 level; CHI3L1 gene variants; peripheral artery disease; association study; haplotype; risk factor circulating YKL-40 level; CHI3L1 gene variants; peripheral artery disease; association study; haplotype; risk factor





Author: Semon Wu 1,2, Lung-An Hsu 3, Shih-Tsung Cheng 4, Ming-Sheng Teng 1, Ching-Hua Yeh 1, Yu-Chen Sun 5, Hsuan-Li Huang 1 and Yu-Lin Ko 1,4,6,*

Source: http://mdpi.com/



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