25-Hydroxyvitamin D3 Levels, BsmI Polymorphism and Insulin Resistance in Brazilian Amazonian ChildrenReport as inadecuate




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Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo 715, CEP 01246-904 São Paulo, Brazil





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Academic Editor: Lu Qi

Abstract Vitamin D is associated with a wide range of other functions beyond bone development. We evaluated the factors associated with 25-hydroxyvitamin D levels in 974 children aged ≤10 years and the impact of BsmI polymorphism of the vitamin D receptor VDR gene rs1544410 on metabolic parameters in a subsample n: 430 with a follow-up 2 years later from the initial population-based cross-sectional study. Multiple linear regression models were used in the analyses. The prevalence 95% CI of vitamin D deficiency, insufficiency and sufficiency of children was 11.1% 9.2–13.2, 21.8% 19.2–24.5 and 67.2% 64.1–70.1, respectively. Overall, 23% of the variation in serum 25-hydroxyvitamin D concentrations was accounted for by BsmI polymorphism β = −0.053 95% CI −0.100, −0.006, maternal schooling ≥9 years β = 0.100 0.039, 0.161, serum vitamin E β = 0.478 0.381, 0.574, total cholesterol concentration β = 0.232 0.072, 0.393 and serum folate β = 0.064 0.013, 0.115. BsmI polymorphism was positively associated with HOMA-IR β = 0.122 0.002, 0.243 and fasting glucose concentration β = 1.696 0.259, 3.133. In conclusion, variables related to socioeconomic level, the presence of the allele risk for BsmI and other nutrient concentrations were associated with serum 25-hydroxyvitamin D concentrations. Our results suggest that BsmI polymorphism is correlated with metabolic outcomes. View Full-Text

Keywords: vitamin D; genetic polymorphism; children; nutrition; insulin resistance vitamin D; genetic polymorphism; children; nutrition; insulin resistance





Author: Fernanda Cobayashi, Bárbara Hatzlhoffer Lourenço and Marly Augusto Cardoso *

Source: http://mdpi.com/



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