Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus ErythematosusReport as inadecuate




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1

Department of Pathology and Center of Infection and Immunology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China

2

Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China





*

Authors to whom correspondence should be addressed.



Academic Editor: Chak-Sing Lau

Abstract Toll-like receptors TLRs are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted. View Full-Text

Keywords: toll-like receptor TLR; systemic lupus erythematosus SLE; anti-nuclear autoantibody ANA; B-1 B cells; transitional B cells; marginal zone B cells MZ B cells; germinal center B cells GC B cells; memory B cells; myeloid differentiation primary response gene 88 MyD88; Unc-93 Homolog B1 C. elegans Unc93b1 toll-like receptor TLR; systemic lupus erythematosus SLE; anti-nuclear autoantibody ANA; B-1 B cells; transitional B cells; marginal zone B cells MZ B cells; germinal center B cells GC B cells; memory B cells; myeloid differentiation primary response gene 88 MyD88; Unc-93 Homolog B1 C. elegans Unc93b1





Author: Kongyang Ma 1, Jingyi Li 2, Yongfei Fang 2,* and Liwei Lu 1,*

Source: http://mdpi.com/



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