Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist PerspectiveReport as inadecuate




Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective - Download this document for free, or read online. Document in PDF available to download.

1

Department of Pathology, University of Otago, Dunedin 9054, New Zealand

2

Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand

3

Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia





*

Author to whom correspondence should be addressed.



Academic Editors: Chris Sobey and Hyun Ah Kim

Abstract Stroke is one of the leading causes of death and long-term disability, with limited treatment options available. Inflammation contributes to damage tissue in the central nervous system across a broad range of neuropathologies, including Alzheimer’s disease, pain, Schizophrenia, and stroke. While the immune system plays an important role in contributing to brain damage produced by ischemia, the damaged brain, in turn, can exert a powerful immune-suppressive effect that promotes infections and threatens the survival of stroke patients. Recently the cholinergic anti-inflammatory pathway, in particular its modulation using α7-nicotinic acetylcholine receptor α7-nAChR ligands, has shown potential as a strategy to dampen the inflammatory response and facilitate functional recovery in stroke patients. Here we discuss the current literature on stroke-induced inflammation and the effects of α7-nAChR modulators on innate immune cells. View Full-Text

Keywords: stroke; inflammation; nicotinic; nicotinic acetylcholine receptor agonist; immune response; myeloid cells stroke; inflammation; nicotinic; nicotinic acetylcholine receptor agonist; immune response; myeloid cells





Author: Silke Neumann 1,2, Nicholas J. Shields 1, Thomas Balle 3, Mary Chebib 3 and Andrew N. Clarkson 2,3,*

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents