Molecular Signature of Indeterminate Thyroid Lesions: Current Methods to Improve Fine Needle Aspiration Cytology FNAC DiagnosisReport as inadecuate


Molecular Signature of Indeterminate Thyroid Lesions: Current Methods to Improve Fine Needle Aspiration Cytology FNAC Diagnosis


Molecular Signature of Indeterminate Thyroid Lesions: Current Methods to Improve Fine Needle Aspiration Cytology FNAC Diagnosis - Download this document for free, or read online. Document in PDF available to download.

Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy





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Academic Editor: Daniela Gabriele Grimm

Abstract Fine needle aspiration cytology FNAC represents the gold standard for determining the nature of thyroid nodules. It is a reliable method with good sensitivity and specificity. However, indeterminate lesions remain a diagnostic challenge and researchers have contributed molecular markers to search for in cytological material to refine FNAC diagnosis and avoid unnecessary surgeries. Nowadays, several -home-made- methods as well as commercial tests are available to investigate the molecular signature of an aspirate. Moreover, other markers i.e., microRNA, and circulating tumor cells have been proposed to discriminate benign from malignant thyroid lesions. Here, we review the literature and provide data from our laboratory on mutational analysis of FNAC material and circulating microRNA expression obtained in the last 6 years. View Full-Text

Keywords: fine needle aspiration cytology FNAC; indeterminate lesions; next generation sequencing; gene expression classifier; microRNAs miRNAs fine needle aspiration cytology FNAC; indeterminate lesions; next generation sequencing; gene expression classifier; microRNAs miRNAs





Author: Silvia Cantara * , Carlotta Marzocchi, Tania Pilli, Sandro Cardinale, Raffaella Forleo, Maria Grazia Castagna and Furio Pacini

Source: http://mdpi.com/



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